Injuries: Isaac Seumalo (foot), Brett Toth (knee), Lane Johnson (questionable), Jack Driscoll (ankle)
Backups: (T): Andre Dillard (G): Jack Anderson (C): Cam Jurgens
Fantasy Impact: The retirement of Pro Bowl RG Brandon Brooks, even after numerous injury-plagued years, is a notable blow. There's still cause for optimism surrounding this unit, though. While Jalen Hurts still has a ways to go in his efforts to prove himself as a franchise QB, his athleticism should be valuable in covering up deficiencies along the O-line. Rookie second-round pick Cam Jurgens will get a chance to develop behind Jason Kelce (on a one-year deal) before taking over.
Injuries: Jack Conklin (kneecap), Chris Hubbard (triceps)
Backups: (T): Chris Hubbard (G): Michael Dunn (C): Ethan Pocic
Fantasy Impact: Losing J.C. Tretter isn't an ideal development, but the Browns still boast one of the top O-lines in the league. LG Joel Bitonio, RG Wyatt Teller, RT Jack Conklin and LT Jedrick Willis are all among the league's best options at their positions, and if a replacement for Tretter can be found, this unit could legitimately be without any real weakness among its starters. That is, of course, dependent on health, and injuries weren't kind to the Browns in 2021. Conklin ultimately being forced to undergo season-ending surgery was a huge blow for Cleveland's offense, but he should be healthy to start the 2022 campaign.
Injuries: Tristan Wirfs (ankle), Sadarius Hutcherson (knee)
Backups: (T): Josh Wells (G): Nick Leverett (C): Robert Hainsey
Fantasy Impact: Tom Brady's return after a brief retirement sets the stage for another competitive season. However, LG Ali Marpet hanging up the cleats leaves another notable void on the roster, and it would be asking a lot for second-round rookie Luke Goedeke to immediately contribute. Tampa Bay's remaining starters on the O-line should still provide more than solid pass protection, but it also wouldn't be a surprise to see the overall quality of the unit drop during the 2022 campaign.
Injuries: Tyrell Crosby (undisclosed), Logan Stenberg (undisclosed)
Backups: (T): Matt Nelson (G): Tommy Kraemer (C): Evan Brown
Fantasy Impact: It's hard to fault the logic of a rebuilding team prioritizing the offensive line, and Penei Sewell is a strong enough prospect for Detroit to be ecstatic about his sliding to No. 7 overall in 2021. Frank Ragnow's health has become a consistent concern, but he's more than reliable when on the field, and back to full health early in the offseason. Further injuries resulted in the O-line being a slight liability at times in 2021, but returning to health could once again propel the unit into top-12 conversation.